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Clinical Correlates of Vascular Parkinsonism Arch Neurol 56:98-102, Winikates,J.&Jancovic,J., 1999 See this aricle in Pubmed Article Abstract These differences in clinical features suggest a different pathogenesis of parkinsonism in these 2 patient groups. The strong evidence of cerebrovascular disease in the VP group and the differences in clinical features support the concept of VP as a distinct clinical entity. We conclude that compared to PD, patients with parkinsonism associated with vascular disease are more likely to present with gait difficulty and postural instability rather than tremor, have a history of stroke and risk factors for stroke and fail to respond to levodopa therapy.

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